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1

P102. Injury Severity Score (ISS) Correlates with Surgical Approach in Subaxial Cervical Trauma

Christopher Chaput, Richard Barber, David Dominguez, Erion Qamirani, Mark Rahm

Journal:

The Spine Journal

Year:

2007

Language:

english

File:

PDF, 120 KB

english, 2007

2

Calculation of relative free energy differences for the covalent hydration of organic compounds: A combined quantum mechanical and free energy perturbation study

Mark D. Erion, M. Rami Reddy

Journal:

Journal of Computational Chemistry

Year:

1995

Language:

english

File:

PDF, 838 KB

english, 1995

3

Modulation of carrageenan-induced hind paw edema by substance P

James P. Gilligan, Susan J. Lovato, Mark D. Erion, Arco Y. Jeng

Journal:

Year:

1994

Language:

english

File:

PDF, 373 KB

english, 1994

4

Efficient synthesis of purine analogues: an FeCl3–SiO2-promoted cyclization reaction of 4,5-diaminopyrimidines with aldehydes leading to 6,8,9-trisubstituted purines

Qun Dang, Brian S Brown, Mark D Erion

Journal:

Tetrahedron Letters

Year:

2000

Language:

english

File:

PDF, 128 KB

english, 2000

5

Adenosine Kinase Inhibitors. 1. Synthesis, Enzyme Inhibition, and Antiseizure Activity of 5-Iodotubercidin Analogues

Ugarkar, Bheemarao G., DaRe, Jay M., Kopcho, Joseph J., Browne, Clinton E., Schanzer, Juergen M., Wiesner, James B., Erion, Mark D.

Journal:

Journal of Medicinal Chemistry

Year:

2000

Language:

english

File:

PDF, 214 KB

english, 2000

6

AMP Deaminase Inhibitors. 3. SAR of 3-(Carboxyarylalkyl)coformycin Aglycon Analogues

Kasibhatla, Srinivas Rao, Bookser, Brett C., Probst, Gary, Appleman, James R., Erion, Mark D.

Journal:

Journal of Medicinal Chemistry

Year:

2000

Language:

english

File:

PDF, 332 KB

english, 2000

7

Solvation free energies calculated using the GB/SA model: Sensitivity of results on charge sets, protocols, and force fields

Reddy, M. Rami, Erion, Mark D., Agarwal, Atul, Viswanadhan, Vellarkad N., McDonald, D. Quentin, Still, W. Clark

Journal:

Journal of Computational Chemistry

Year:

1998

Language:

english

File:

PDF, 236 KB

english, 1998

8

Calculation of relative solvation free energy differences by thermodynamic perturbation method: Dependence of free energy results on simulation length

Reddy, M. Rami, Erion, Mark D.

Journal:

Journal of Computational Chemistry

Year:

1999

Language:

english

File:

PDF, 212 KB

english, 1999

9

ChemInform Abstract: Synthesis of Phosphonate 3-Phthalidyl Esters as Prodrugs for Potential Intracellular Delivery of Phosphonates.

Qun Dang, Brian S. Brown, Paul D. van Poelje, Timothy J. Colby, Mark D. Erion

Journal:

Year:

1999

File:

PDF, 30 KB

1999

10

ChemInform Abstract: Efficient Synthesis of Purines and Purine Nucleosides via an Inverse Electron Demand Diels—Alder Reaction.

Qun Dang, Yan Liu, Mark D. Erion

Journal:

Year:

1999

File:

PDF, 33 KB

1999

11

ChemInform Abstract: AMP Deaminase Inhibitors. Part 2. Initial Discovery of a Non-Nucleotide Transition-State Inhibitor Series.

Brett C. Bookser, Srinivas Rao Kasibhatla, James R. Appleman, Mark D. Erion

Journal:

Year:

2000

File:

PDF, 32 KB

2000

12

ChemInform Abstract: AMP Deaminase Inhibitors. Part 3. SAR of 3-(Carboxyarylalkyl)coformycin Aglycon Analogues.

Srinivas Rao Kasibhatla, Brett C. Bookser, Gary Probst, James R. Appleman, Mark D. Erion

Journal:

Year:

2000

Language:

english

File:

PDF, 34 KB

english, 2000

13

ChemInform Abstract: AMP Deaminase Inhibitors. Part 4. Further N3-Substituted Coformycin Aglycon Analogues: N3-Alkylmalonates as Ribose 5′-Monophosphate Mimetics.

Brett C. Bookser, Srinivas Rao Kasibhatla, Mark D. Erion

Journal:

Year:

2000

File:

PDF, 37 KB

2000

14

ChemInform Abstract: Efficient Synthesis of Purine Analogues: An FeCl3—SiO2-Promoted Cyclization Reaction of 4,5-Diaminopyrimidines with Aldehydes Leading to 6,8,9-Trisubstituted Purines.

Qun Dang, Brian S. Brown, Mark D. Erion

Journal:

Year:

2000

File:

PDF, 33 KB

2000

15

ChemInform Abstract: AMP Deaminase Inhibitors. Part 5. Design, Synthesis, and SAR of a Highly Potent Inhibitor Series (I) and (II).

Srinivas Rao Kasibhatla, Brett C. Bookser, Wei Xiao, Mark D. Erion

Journal:

Year:

2001

File:

PDF, 27 KB

2001

16

ChemInform Abstract: Synthesis of 3′-Amino-3′-deoxyguanosine and 3′-Amino-3′-deoxyxyloguanosine Monophosphate Hepdirect Prodrugs from Guanosine.

Brett C. Bookser, Nicholas B. Raffaele, K. Raja Reddy, Kevin Fan, Wenjian Huang, Mark D. Erion

Journal:

Year:

2010

File:

PDF, 20 KB

2010

17

Reduction of hepatic steatosis in rats and mice after treatment with a liver-targeted thyroid hormone receptor agonist

Edward E. Cable, Patricia D. Finn, Jeffrey W. Stebbins, Jinzhao Hou, Bruce R. Ito, Paul D. van Poelje, David L. Linemeyer, Mark D. Erion

Journal:

Year:

2009

Language:

english

File:

PDF, 704 KB

english, 2009

18

Ab initio quantum mechanics-based free energy perturbation method for calculating relative solvation free energies

M. Rami Reddy, U. C. Singh, Mark D. Erion

Journal:

Journal of Computational Chemistry

Year:

2007

Language:

english

File:

PDF, 111 KB

english, 2007

19

Probing the conformational space available to inhibitors in the thermolysin active site using Monte Carlo/energy minimization techniques

Wayne C. Guida, Regine S. Bohacek, Mark D. Erion

Journal:

Journal of Computational Chemistry

Year:

1992

Language:

english

File:

PDF, 1.12 MB

english, 1992

20

Assessment of methods used for predicting lipophilicity: Application to nucleosides and nucleoside bases

Vellarkad N. Viswanadhan, M. Rami Reddy, Russell J. Bacquet, Mark D. Erion

Journal:

Journal of Computational Chemistry

Year:

1993

Language:

english

File:

PDF, 728 KB

english, 1993

21

A radioimmunoassay for measuring α-amidating enzyme activity

Arco Y. Jeng, Mary Wong, Susan J. Lovato, Mark D. Erion, James P. Gilligan

Journal:

Analytical Biochemistry

Year:

1990

Language:

english

File:

PDF, 558 KB

english, 1990

22

Bis[(para-methoxy)benzyl] phosphonate prodrugs with improved stability and enhanced cell penetration

Qun Dang, Yan Liu, Robert M. Rydzewski, Brian S. Brown, Edward Robinson, Paul D. van Poelje, Timothy J. Colby, Mark D. Erion

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 154 KB

english, 2007

23

Stereoselective synthesis of nucleoside monophosphate HepDirect™ prodrugs

K. Raja Reddy, Serge H. Boyer, Mark D. Erion

Journal:

Tetrahedron Letters

Year:

2005

Language:

english

File:

PDF, 105 KB

english, 2005

24

An unexpected cyclization discovered during the synthesis of 8-substituted purines from a 4,5-diaminopyrimidine

Qun Dang, Robert M. Rydzewski, Daniel K. Cashion, Mark D. Erion

Journal:

Tetrahedron Letters

Year:

2008

Language:

english

File:

PDF, 105 KB

english, 2008

25

An efficient method for the conversion of alkylmercuric halides into olefins

Mark D. Erion, John E. McMurry

Journal:

Tetrahedron Letters

Year:

1985

Language:

english

File:

PDF, 189 KB

english, 1985

26

Stereoselective synthesis of 4-C-methyl-2,3,5-tri-O-benzyl-d-ribofuranose and 4-C-methyl-2,3,5-tri-O-benzyl-l-lyxofuranose

Serge H Boyer, Bheemarao G Ugarkar, Mark D Erion

Journal:

Tetrahedron Letters

Year:

2003

Language:

english

File:

PDF, 231 KB

english, 2003

27

Synthesis of phosphonate 3-phthalidyl esters as prodrugs for potential intracellular delivery of phosphonates

Qun Dang, Brian S. Brown, Paul D. van Poelje, Timothy J. Colby, Mark D. Erion

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 352 KB

english, 1999

28

[177Lu-DOTA0,Tyr3]octreotate: comparison with [111In-DTPA0]octreotide in patients

Dik J. Kwekkeboom, Willem H. Bakker, Peter P. Kooij, Mark W. Konijnenberg, Ananth Srinivasan, Jack L. Erion, Michelle A. Schmidt, Joe L. Bugaj, Marion de Jong, Eric P. Krenning

Journal:

European Journal of Nuclear Medicine and Molecular Imaging

Year:

2001

Language:

english

File:

PDF, 96 KB

english, 2001

29

Delivery of high levels of anti-proliferative nucleoside triphosphates to CYP3A-expressing cells as a potential treatment for hepatocellular carcinoma

Deidre A. MacKenna, Annika Montag, Serge H. Boyer, David L. Linemeyer, Mark D. Erion

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2009

Language:

english

File:

PDF, 584 KB

english, 2009

30

Relative solvation free energies calculated using an ab initio QM/MM-based free energy perturbation method: dependence of results on simulation length

M. Rami Reddy, Mark D. Erion

Journal:

Journal of Computer-Aided Molecular Design

Year:

2009

Language:

english

File:

PDF, 276 KB

english, 2009

31

Use of a QM/MM-Based FEP Method to Evaluate the Anomalous Hydration Behavior of Simple Alkyl Amines and Amides: Application to the Design of FBPase Inhibitors for the Treatment of Type-2 Diabetes

Reddy, M. Rami, Singh, U. Chandra, Erion, Mark D.

Journal:

Journal of the American Chemical Society

Year:

2011

Language:

english

File:

PDF, 682 KB

english, 2011

32

Structure-based design of inhibitors of purine nucleoside phosphorylase. 1. 9-(Arylmethyl) derivatives of 9-deazaguanine

Montgomery, John A., Niwas, Shri, Rose, Jerry D., Secrist, John A., Babu, Y. Sudhakar, Bugg, Charles E., Erion, Mark D., Guida, Wayne C., Ealick, Steven E.

Journal:

Journal of Medicinal Chemistry

Year:

1993

Language:

english

File:

PDF, 3.31 MB

english, 1993

33

Adenosine Kinase Inhibitors. 3. Synthesis, SAR, and Antiinflammatory Activity of a Series of l-Lyxofuranosyl Nucleosides

Ugarkar, Bheemarao G., Castellino, Angelo J., DaRe, Jay S., Ramirez-Weinhouse, Michele, Kopcho, Joseph J., Rosengren, Sanna, Erion, Mark D.

Journal:

Journal of Medicinal Chemistry

Year:

2003

Language:

english

File:

PDF, 183 KB

english, 2003

34

Adenosine Kinase Inhibitors. 6. Synthesis, Water Solubility, and Antinociceptive Activity of 5-Phenyl-7-(5-deoxy-β-d-ribofuranosyl)pyrrolo[2,3-d]pyrimidines Substituted at C4 with Glycinamides and Related Compounds

Bookser, Brett C., Ugarkar, Bheemarao G., Matelich, Michael C., Lemus, Robert H., Allan, Matthew, Tsuchiya, Megumi, Nakane, Masami, Nagahisa, Atsushi, Wiesner, James B., Erion, Mark D.

Journal:

Journal of Medicinal Chemistry

Year:

2005

Language:

english

File:

PDF, 218 KB

english, 2005

35

The structure of human 5′-deoxy-5′-methylthioadenosine phosphorylase at 1.7 Å resolution provides insights into substrate binding and catalysis

Todd C Appleby, Mark D Erion, Steven E Ealick

Journal:

Year:

1999

Language:

english

File:

PDF, 777 KB

english, 1999

36

Calculation of Relative Hydration Free Energy Differences for Heteroaromatic Compounds: Use in the Design of Adenosine Deaminase and Cytidine Deaminase Inhibitors

Erion, Mark D., Reddy, M. Rami

Journal:

Journal of the American Chemical Society

Year:

1998

Language:

english

File:

PDF, 218 KB

english, 1998

37

Optimization of co-agonism at GLP-1 and glucagon receptors to safely maximize weight reduction in DIO-rodents

Jonathan W. Day, Vasily Gelfanov, David Smiley, Paul E. Carrington, George Eiermann, Gary Chicchi, Mark D. Erion, Jas Gidda, Nancy A. Thornberry, Matthias H. Tschöp, Donald J. Marsh, Ranabir SinhaRoy,

Journal:

Year:

2012

Language:

english

File:

PDF, 504 KB

english, 2012

38

Isolation of a Family of Organic Anion Transporters from Human Liver and Kidney

William Sun, Rong Rong Wu, Paul D. van Poelje, Mark D. Erion

Journal:

Biochemical and Biophysical Research Communications

Year:

2001

Language:

english

File:

PDF, 226 KB

english, 2001

39

Structure-activity relationships for glycine-extended peptides and the α-amidating enzyme derived from medullary thyroid CA-77 cells

Paul P. Tamburini, Barry N. Jones, Angelo P. Consalvo, Stanley D. Young, Susan J. Lovato, James P. Gilligan, Lawrence P. Wennogle, Mark Erion, Arco Y. Jeng

Journal:

Archives of Biochemistry and Biophysics

Year:

1988

Language:

english

File:

PDF, 880 KB

english, 1988

40

Purine Nucleoside Phosphorylase. 2. Catalytic Mechanism †

Erion, Mark D., Stoeckler, Johanna D., Guida, Wayne C., Walter, Richard L.

Journal:

Year:

1997

Language:

english

File:

PDF, 429 KB

english, 1997

41

Synthesis of 3′-Amino-3′-Deoxyguanosine and 3′-Amino-3′-Deoxyxyloguanosine Monophosphate Hepdirect Prodrugs from Guanosine

Bookser, Brett C., Raffaele, Nicholas B., Reddy, K. Raja, Fan, Kevin, Huang, Wenjian, Erion, Mark D.

Journal:

Nucleosides Nucleotides & Nucleic Acids

Year:

2009

Language:

english

File:

PDF, 624 KB

english, 2009

42

pH- and time-dependent inhibition of rat kidney neutral endoprotease 24.11 by thiorphan and phosphoramidon

Arco Y. Jeng, Justin Ansell, Mark D. Erion

Journal:

Year:

1989

Language:

english

File:

PDF, 283 KB

english, 1989

43

Fructose-1,6-bisphosphatase as a therapeutic target for type 2 diabetes

Paul D. van Poelje, Qun Dang, Mark D. Erion

Journal:

Drug Discovery Today: Therapeutic Strategies

Year:

2007

Language:

english

File:

PDF, 342 KB

english, 2007

44

524 MB07133: a hepdirect™ prodrug of cytarabine monophosphate for use in hepatocellular carcinoma

Deidre A. MacKenna, Serge H. Boyer, Annika C. Montag, Barbara Treash-Osio, Paul A. Rolzin, David L. Linemeyer, Mark D. Erion

Journal:

Year:

2003

Language:

english

File:

PDF, 147 KB

english, 2003

45

Application of X-Ray Crystallographic Methods in the Design of Purine Nucleoside Phosphorylase Inhibitors

STEVEN E. EALICK, Y. S. BABU, CHARLES E. BUGG, MARK D. ERION, WAYNE G. GUIDA, JOHN A. MONTGOMERY, JOHN A. SECRIST III

Journal:

Annals of the New York Academy of Sciences

Year:

1993

Language:

english

File:

PDF, 1.02 MB

english, 1993

46

Calculation of Relative Binding Free Energy Differences for Fructose 1,6-Bisphosphatase Inhibitors Using the Thermodynamic Cycle Perturbation Approach

Reddy, M. Rami, Erion, Mark D.

Journal:

Journal of the American Chemical Society

Year:

2001

Language:

english

File:

PDF, 163 KB

english, 2001

47

Structure-Guided Design of AMP Mimics That Inhibit Fructose-1,6-bisphosphatase with High Affinity and Specificity

Erion, Mark D., Dang, Qun, Reddy, M. Rami, Kasibhatla, Srinivas Rao, Huang, Jingwei, Lipscomb, William N., van Poelje, Paul D.

Journal:

Journal of the American Chemical Society

Year:

2007

Language:

english

File:

PDF, 419 KB

english, 2007

48

Development of a Quantum Mechanics-Based Free-Energy Perturbation Method: Use in the Calculation of Relative Solvation Free Energies

Reddy, M. Rami, Singh, U. C., Erion, Mark D.

Journal:

Journal of the American Chemical Society

Year:

2004

Language:

english

File:

PDF, 33 KB

english, 2004

49

Computer-Assisted Scanning of Ligand Interactions: Analysis of the Fructose 1,6-Bisphosphatase−AMP Complex Using Free Energy Calculations

Erion, Mark D., van Poelje, Paul D., Reddy, M. Rami

Journal:

Journal of the American Chemical Society

Year:

2000

Language:

english

File:

PDF, 49 KB

english, 2000

50

Fructose-1,6-bisphosphatase Inhibitors. 1. Purine Phosphonic Acids as Novel AMP Mimics

Dang, Qun, Brown, Brian S., Liu, Yan, Rydzewski, Robert M., Robinson, Edward D., Poelje, Paul D. van, Reddy, M. Rami, Erion, Mark D.

Journal:

Journal of Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 629 KB

english, 2009